Expression of RNF145 in cancer - Summary - The Human Protein Atlas

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RNF145

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF145
Gene description	Ring finger protein 145
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic staining in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA036562
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036562

GENE INFORMATION
Gene name	RNF145 (HGNC Symbol)
Synonyms	FLJ31951
Description	Ring finger protein 145 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q33.3
Chromosome location (bp)	159157409 - 159210053
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145860 (version 83.38)
Entrez gene	153830
UniProt	Q96MT1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96MT1
Antibodypedia	RNF145 antibodies

PROTEIN BROWSER

RNF145-001	RNF145-002	RNF145-003	RNF145-004	RNF145-005	RNF145-006	RNF145-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF145-001 ENSP00000274542 ENST00000274542	Q96MT1 [Direct mapping] RING finger protein 145 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	691 aa 78.9 kDa	No	>9
RNF145-002 ENSP00000409064 ENST00000424310	Q96MT1 [Direct mapping] RING finger protein 145 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	663 aa 75.6 kDa	No	>9
RNF145-003 ENSP00000430955 ENST00000518802	Q96MT1 [Direct mapping] RING finger protein 145 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	693 aa 79.2 kDa	No	>9
RNF145-004 ENSP00000429071 ENST00000520638	Q96MT1 [Direct mapping] RING finger protein 145 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	677 aa 77.3 kDa	No	>9
RNF145-005 ENSP00000430397 ENST00000519865	Q96MT1 [Direct mapping] RING finger protein 145 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	663 aa 75.6 kDa	No	>9
RNF145-006 ENSP00000430753 ENST00000521606	Q96MT1 [Direct mapping] RING finger protein 145 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	680 aa 77.6 kDa	No	>9
RNF145-201 ENSP00000482720 ENST00000611185	Q96MT1 [Direct mapping] RING finger protein 145 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	663 aa 75.6 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.