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Prostate cancers and a few cases of malignant melanomas showed strong cytoplasmic and membranous immunoreactivity. Renal cancers were moderately stained. The remaining malignant cells were weakly stained or generally negative.
GENE INFORMATION
Gene name
GLRA1 (HGNC Symbol)
Synonyms
STHE
Description
Glycine receptor, alpha 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]