Expression of G3BP1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

G3BP1

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	G3BP1
Gene description	GTPase activating protein (SH3 domain) binding protein 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA004052 , CAB037068
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004052	CAB037068

GENE INFORMATION
Gene name	G3BP1 (HGNC Symbol)
Synonyms	G3BP, HDH-VIII
Description	GTPase activating protein (SH3 domain) binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q33.1
Chromosome location (bp)	151771045 - 151812785
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145907 (version 83.38)
Entrez gene	10146
UniProt	Q13283 (UniProt - Evidence at protein level)
neXtProt	NX_Q13283
Antibodypedia	G3BP1 antibodies

PROTEIN BROWSER

G3BP1-001	G3BP1-002	G3BP1-007	G3BP1-008	G3BP1-009	G3BP1-012	G3BP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
G3BP1-001 ENSP00000377681 ENST00000394123	Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Q5U0Q1 [Target identity:100%; Query identity:100%] Putative uncharacterized protein DKFZp686L1159; Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003729 [mRNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004519 [endonuclease activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006810 [transport] GO:0007265 [Ras protein signal transduction] GO:0010494 [cytoplasmic stress granule] GO:0032508 [DNA duplex unwinding] GO:0044822 [poly(A) RNA binding] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	466 aa 52.2 kDa	No	0
G3BP1-002 ENSP00000348578 ENST00000356245	Q13283 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Q5U0Q1 [Target identity:100%; Query identity:100%] Putative uncharacterized protein DKFZp686L1159; Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004519 [endonuclease activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006810 [transport] GO:0007265 [Ras protein signal transduction] GO:0032508 [DNA duplex unwinding] GO:0044822 [poly(A) RNA binding] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	466 aa 52.2 kDa	No	0
G3BP1-007 ENSP00000430738 ENST00000523519	E5RIF8 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	106 aa 12 kDa	No	0
G3BP1-008 ENSP00000429920 ENST00000520578	E5RH42 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	117 aa 13.3 kDa	No	0
G3BP1-009 ENSP00000429250 ENST00000507878	E5RIZ6 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	148 aa 17 kDa	No	0
G3BP1-012 ENSP00000428469 ENST00000520006	E5RI46 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	105 aa 11.8 kDa	No	0
G3BP1-201 ENSP00000486887 ENST00000627077	E5RH00 [Direct mapping] Ras GTPase-activating protein-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.