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ZNF300

GENERAL INFORMATION

Gene name

 ZNF300

Gene description

 Zinc finger protein 300

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA051777
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051777

GENE INFORMATION

Gene name

 ZNF300

Synonyms

Description

 Zinc finger protein 300 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Chromosome

 5

Cytoband

 q33.1

Chromosome location (bp)

 150894392 - 150904983

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145908 (version 83.38)

Entrez gene

 91975

UniProt

 Q96RE9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RE9

Antibodypedia

 ZNF300 antibodies

PROTEIN BROWSER
ZNF300-001
ZNF300-002
ZNF300-201
ZNF300-202
ZNF300-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF300-001
ENSP00000377773
ENST00000394226
A0A0A0MS50 [Direct mapping]
Zinc finger protein 300
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 604 aa
68.7 kDa 		No 0
ZNF300-002
ENSP00000414195
ENST00000427179
F8WE31 [Direct mapping]
Zinc finger protein 300
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
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 90 aa
10.5 kDa 		No 0
ZNF300-201
ENSP00000274599
ENST00000274599
Q96RE9 [Direct mapping]
Zinc finger protein 300
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 604 aa
68.7 kDa 		No 0
ZNF300-202
ENSP00000392593
ENST00000418587
Q96RE9 [Direct mapping]
Zinc finger protein 300
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 568 aa
64.5 kDa 		No 0
ZNF300-203
ENSP00000397178
ENST00000446148
Q96RE9 [Direct mapping]
Zinc finger protein 300
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 620 aa
70.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.