Expression of FAM50B in cancer - Summary - The Human Protein Atlas

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FAM50B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM50B
Gene description	Family with sequence similarity 50, member B
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA067817
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA067817

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Few cases of colorectal and prostate cancers show weak to moderate cytoplasmic and/or membranous staining. Few cases of melanomas along with squamous cell carcinomas showed weak to moderate nuclear positivity. Remaining cancer tissues were negative.

GENE INFORMATION
Gene name	FAM50B (HGNC Symbol)
Synonyms	D6S2654E, X5L
Description	Family with sequence similarity 50, member B (HGNC Symbol)
Entrez gene summary	This gene contains an intronless ORF that arose from ancestral retroposition. The encoded protein is related to a plant protein that plays a role in the circadian clock. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and paternally expressed in many tissues. [provided by RefSeq, Nov 2015]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	3849386 - 3851317
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145945 (version 83.38)
Entrez gene	26240
UniProt	Q9Y247 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y247
Antibodypedia	FAM50B antibodies

PROTEIN BROWSER

FAM50B-001	FAM50B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM50B-001 ENSP00000369625 ENST00000380272	Q9Y247 [Direct mapping] Protein FAM50B A0A024QZY3 [Target identity:100%; Query identity:100%] Family with sequence similarity 50, member B, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	325 aa 38.7 kDa	No	0
FAM50B-002 ENSP00000369627 ENST00000380274	Q9Y247 [Direct mapping] Protein FAM50B A0A024QZY3 [Target identity:100%; Query identity:100%] Family with sequence similarity 50, member B, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	325 aa 38.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.