Cell atlas - FARS2 - The Human Protein Atlas

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FARS2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	FARS2
Gene description	Phenylalanyl-tRNA synthetase 2, mitochondrial
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028836
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028836	U-2 OS	Plasma membrane
	HPA028836	U-251 MG	No staining

GENE INFORMATION
Gene name	FARS2 (HGNC Symbol)
Synonyms	dJ236A3.1, FARS1
Description	Phenylalanyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p25.1
Chromosome location (bp)	5261044 - 5771580
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145982 (version 83.38)
Entrez gene	10667
UniProt	O95363 (UniProt - Evidence at protein level)
neXtProt	NX_O95363
Antibodypedia	FARS2 antibodies

PROTEIN BROWSER

FARS2-001	FARS2-002	FARS2-003	FARS2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FARS2-001 ENSP00000274680 ENST00000274680	O95363 [Direct mapping] Phenylalanine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004826 [phenylalanine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006432 [phenylalanyl-tRNA aminoacylation] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0043039 [tRNA aminoacylation] Show all	451 aa 52.4 kDa	No	0
FARS2-002 ENSP00000392525 ENST00000445533	Q5JRF7 [Direct mapping] Phenylalanine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0043039 [tRNA aminoacylation] Show all	101 aa 11.6 kDa	No	0
FARS2-003 ENSP00000316335 ENST00000324331	O95363 [Direct mapping] Phenylalanine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004826 [phenylalanine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006432 [phenylalanyl-tRNA aminoacylation] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0043039 [tRNA aminoacylation] Show all	451 aa 52.4 kDa	No	0
FARS2-004 ENSP00000473394 ENST00000602691	R4GMX6 [Direct mapping] Phenylalanine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] Show all	47 aa 5.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.