Expression of RNF44 in cancer - Summary - The Human Protein Atlas

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RNF44

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF44
Gene description	Ring finger protein 44
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038981
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and liver cancer (unfavourable).
Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038981

GENE INFORMATION
Gene name	RNF44 (HGNC Symbol)
Synonyms	KIAA1100
Description	Ring finger protein 44 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	176526697 - 176538025
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146083 (version 83.38)
Entrez gene	22838
UniProt	Q7L0R7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7L0R7
Antibodypedia	RNF44 antibodies

PROTEIN BROWSER

RNF44-001	RNF44-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF44-001 ENSP00000274811 ENST00000274811	Q7L0R7 [Direct mapping] RING finger protein 44 A0A024R7Q1 [Target identity:100%; Query identity:100%] Ring finger protein 44, isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	432 aa 47.7 kDa	No	0
RNF44-007 ENSP00000425253 ENST00000506378	H0Y9W0 [Direct mapping] RING finger protein 44 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	226 aa 25.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.