Expression of RASGEF1C in cancer - Summary

GENERAL INFORMATION
Gene name	RASGEF1C
Gene description	RasGEF domain family, member 1C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (BEWO, SCLC-21H, U-2 OS)
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in neurons and Leydig cells in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA028242
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA028242

GENE INFORMATION
Gene name	RASGEF1C (HGNC Symbol)
Synonyms	FLJ35841
Description	RasGEF domain family, member 1C (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	180100791 - 180209153
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000146090 (version 83.38)
Entrez gene	255426
UniProt	Q8N431 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N431
Antibodypedia	RASGEF1C antibodies

PROTEIN BROWSER

RASGEF1C-001	RASGEF1C-002	RASGEF1C-003	RASGEF1C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RASGEF1C-001 ENSP00000377037 ENST00000393371	Q8N431 [Direct mapping] Ras-GEF domain-containing family member 1C Show all	Predicted intracellular proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	466 aa 52.9 kDa	No	0
RASGEF1C-002 ENSP00000354963 ENST00000361132	Q8N431 [Direct mapping] Ras-GEF domain-containing family member 1C Show all	Predicted intracellular proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	466 aa 52.9 kDa	No	0
RASGEF1C-003 ENSP00000429114 ENST00000522500	Q8N431 [Direct mapping] Ras-GEF domain-containing family member 1C Show all	Predicted intracellular proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	315 aa 36 kDa	No	0
RASGEF1C-201 ENSP00000481349 ENST00000615330	I6L9E5 [Direct mapping] RASGEF1C protein; Ras-GEF domain-containing family member 1C Show all	Predicted intracellular proteins Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	238 aa 26.7 kDa	No	0