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PPP1R18

GENERAL INFORMATION

Gene name

 PPP1R18

Gene description

 Protein phosphatase 1, regulatory subunit 18

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA044745 , HPA051000
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA044745
HPA051000

GENE INFORMATION

Gene name

 PPP1R18 (HGNC Symbol)

Synonyms

 KIAA1949, phostensin

Description

 Protein phosphatase 1, regulatory subunit 18 (HGNC Symbol)

Entrez gene summary

 Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 30676389 - 30687895

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146112 (version 83.38)

Entrez gene

 170954

UniProt

 Q6NYC8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6NYC8

Antibodypedia

 PPP1R18 antibodies

PROTEIN BROWSER
PPP1R18-001
PPP1R18-002
PPP1R18-005
PPP1R18-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R18-001
ENSP00000274853
ENST00000274853
Q6NYC8 [Direct mapping]
Phostensin
A0A024RCJ8 [Target identity:100%; Query identity:100%]
HCG1821276, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0019902 [phosphatase binding]
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 613 aa
67.9 kDa 		No 0
PPP1R18-002
ENSP00000382150
ENST00000399199
Q6NYC8 [Direct mapping]
Phostensin
A0A024RCJ8 [Target identity:100%; Query identity:100%]
HCG1821276, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0019902 [phosphatase binding]
Show all
 613 aa
67.9 kDa 		No 0
PPP1R18-005
ENSP00000482578
ENST00000615892
Q6NYC8 [Direct mapping]
Phostensin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0019902 [phosphatase binding]
Show all
 165 aa
17.8 kDa 		No 0
PPP1R18-201
ENSP00000480270
ENST00000615527
Q6NYC8 [Direct mapping]
Phostensin
A0A024RCJ8 [Target identity:100%; Query identity:100%]
HCG1821276, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0019902 [phosphatase binding]
Show all
 613 aa
67.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.