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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SCUBE3
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SCUBE3

Gene description

Signal peptide, CUB domain, EGF-like 3

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (thyroid cancer)
HPA (cell line):Group enriched (AF22, ASC TERT1, U-138 MG, WM-115)
HPA (normal tissue):Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA040606
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PROGNOSTIC SUMMARY

Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040606

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Weak to moderate cytoplasmic positivity was observed in most cancer cells. Several cases of squamous cell carcinomas and urothelial cancers showed distinct cell membranous staining. Gliomas were in general negative.

GENE INFORMATION

Gene name

SCUBE3 (HGNC Symbol)

Synonyms

CEGF3, FLJ34743

Description

Signal peptide, CUB domain, EGF-like 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

6

Cytoband

p21.31

Chromosome location (bp)

35214419 - 35253079

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146197 (version 83.38)

Entrez gene

222663

UniProt

Q8IX30 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IX30

Antibodypedia

SCUBE3 antibodies

PROTEIN BROWSER

SCUBE3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCUBE3-001
ENSP00000274938
ENST00000274938
Q8IX30 [Direct mapping]
Signal peptide, CUB and EGF-like domain-containing protein 3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0009986 [cell surface]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
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993 aa
109.3 kDa
Yes 0

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