Expression of NFKBIE in cancer - Summary - The Human Protein Atlas

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NFKBIE

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NFKBIE
Gene description	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with high levels in lymphoid tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA002692 , HPA005941 , CAB010272
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), breast cancer (favourable), liver cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Breast cancer p<0.001 Liver cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002692	HPA005941	CAB010272

GENE INFORMATION
Gene name	NFKBIE (HGNC Symbol)
Synonyms	IKBE
Description	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	44258166 - 44265788
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146232 (version 83.38)
Entrez gene	4794
UniProt	O00221 (UniProt - Evidence at protein level)
neXtProt	NX_O00221
Antibodypedia	NFKBIE antibodies

PROTEIN BROWSER

NFKBIE-001	NFKBIE-003	NFKBIE-004	NFKBIE-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NFKBIE-001 ENSP00000275015 ENST00000275015	O00221 [Direct mapping] NF-kappa-B inhibitor epsilon A0A024RD24 [Target identity:100%; Query identity:100%] Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0042942 [D-serine transport] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0048471 [perinuclear region of cytoplasm] Show all	500 aa 52.9 kDa	No	0
NFKBIE-003 ENSP00000394658 ENST00000443607	H0Y4W4 [Direct mapping] NF-kappa-B inhibitor epsilon Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		55 aa 5.9 kDa	No	0
NFKBIE-004 ENSP00000480216 ENST00000619360	Q7LC14 [Direct mapping] NF-kappa-B inhibitor epsilon; NFKBIE protein; cDNA FLJ61640, highly similar to NF-kappa-B inhibitor epsilon Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	361 aa 38.5 kDa	No	0
NFKBIE-201 ENSP00000479764 ENST00000616555	A0A087WVX9 [Direct mapping] NF-kappa-B inhibitor epsilon Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	499 aa 52.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.