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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PHIP
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PHIP

Gene description

Pleckstrin homology domain interacting protein

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 2 antibodies.
HPA019140 , HPA019838
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY

HPA019140
HPA019838

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate nuclear immunoreactivity with additional cytoplasmic staining in several cases. Several carcinoids, along with a few lung, stomach, skin, urothelial and colorectal cancers were strongly stained. Several liver cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed weak to moderate nuclear staining.

GENE INFORMATION

Gene name

PHIP (HGNC Symbol)

Synonyms

BRWD2, DCAF14, FLJ20705, ndrp, WDR11

Description

Pleckstrin homology domain interacting protein (HGNC Symbol)

Entrez gene summary

PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]

Chromosome

6

Cytoband

q14.1

Chromosome location (bp)

78935867 - 79078236

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146247 (version 83.38)

Entrez gene

55023

UniProt

Q8WWQ0 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WWQ0

Antibodypedia

PHIP antibodies

PROTEIN BROWSER

PHIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHIP-001
ENSP00000275034
ENST00000275034
Q8WWQ0 [Direct mapping]
PH-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006606 [protein import into nucleus]
GO:0007010 [cytoskeleton organization]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0022604 [regulation of cell morphogenesis]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0040008 [regulation of growth]
GO:0043066 [negative regulation of apoptotic process]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
GO:0070577 [lysine-acetylated histone binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
1821 aa
206.7 kDa
No 0

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