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Most cancer tissues showed weak to moderate nuclear immunoreactivity with additional cytoplasmic staining in several cases. Several carcinoids, along with a few lung, stomach, skin, urothelial and colorectal cancers were strongly stained. Several liver cancers were negative.
Cancer tissues showed weak to moderate nuclear staining.
GENE INFORMATION
Gene name
PHIP (HGNC Symbol)
Synonyms
BRWD2, DCAF14, FLJ20705, ndrp, WDR11
Description
Pleckstrin homology domain interacting protein (HGNC Symbol)
Entrez gene summary
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]