Expression of PM20D2 in cancer - Summary - The Human Protein Atlas

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PM20D2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PM20D2
Gene description	Peptidase M20 domain containing 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA030327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030327

GENE INFORMATION
Gene name	PM20D2 (HGNC Symbol)
Synonyms	ACY1L2, bA63L7.3
Description	Peptidase M20 domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q15
Chromosome location (bp)	89146050 - 89165565
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146281 (version 83.38)
Entrez gene	135293
UniProt	Q8IYS1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYS1
Antibodypedia	PM20D2 antibodies

PROTEIN BROWSER

PM20D2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PM20D2-001 ENSP00000275072 ENST00000275072	Q8IYS1 [Direct mapping] Peptidase M20 domain-containing protein 2 Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	436 aa 47.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.