Expression of ARHGAP18 in cancer - Summary

GENERAL INFORMATION
Gene name	ARHGAP18
Gene description	Rho GTPase activating protein 18
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with additional membranous expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA031595
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA031595

GENE INFORMATION
Gene name	ARHGAP18 (HGNC Symbol)
Synonyms	bA307O14.2, MacGAP
Description	Rho GTPase activating protein 18 (HGNC Symbol)
Entrez gene summary	ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]
Chromosome	6
Cytoband	q22.33
Chromosome location (bp)	129576132 - 129710225
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146376 (version 83.38)
Entrez gene	93663
UniProt	Q8N392 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N392
Antibodypedia	ARHGAP18 antibodies

PROTEIN BROWSER

ARHGAP18-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP18-001 ENSP00000357131 ENST00000368149	Q8N392 [Direct mapping] Rho GTPase-activating protein 18 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008360 [regulation of cell shape] GO:0030833 [regulation of actin filament polymerization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:2000145 [regulation of cell motility] Show all	663 aa 75 kDa	No	0