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TIAM2

GENERAL INFORMATION

Gene name

 TIAM2

Gene description

 T-cell lymphoma invasion and metastasis 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, HDLM-2, RH-30)
HPA (normal tissue):Tissue enhanced (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, highly abundant in the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA013903
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Carcinoid

STAINING SUMMARY
HPA013903

GENE INFORMATION

Gene name

 TIAM2 (HGNC Symbol)

Synonyms

 STEF

Description

 T-cell lymphoma invasion and metastasis 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

Chromosome location (bp)

 154832697 - 155257723

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146426 (version 83.38)

Entrez gene

 26230

UniProt

 Q8IVF5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IVF5

Antibodypedia

 TIAM2 antibodies

PROTEIN BROWSER
«
TIAM2-003
TIAM2-004
TIAM2-005
TIAM2-006
TIAM2-007
TIAM2-009
TIAM2-010
TIAM2-012
TIAM2-014
TIAM2-015
TIAM2-017
TIAM2-018
TIAM2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TIAM2-003
ENSP00000407183
ENST00000456877
Q8IVF5 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1013 aa
114.1 kDa 		No 0
TIAM2-004
ENSP00000435335
ENST00000528391
E9PKT1 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1045 aa
117.4 kDa 		No 0
TIAM2-005
ENSP00000437188
ENST00000461783
Q8IVF5 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1701 aa
190.1 kDa 		No 0
TIAM2-006
ENSP00000434901
ENST00000528535
E9PMZ8 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1367 aa
153 kDa 		No 0
TIAM2-007
ENSP00000433348
ENST00000529824
Q8IVF5 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1730 aa
193.4 kDa 		No 0
TIAM2-009
ENSP00000353528
ENST00000360366
Q8IVF5 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1725 aa
192.6 kDa 		No 0
TIAM2-010
ENSP00000275246
ENST00000275246
Q8IVF5 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 626 aa
70.8 kDa 		No 0
TIAM2-012
ENSP00000444040
ENST00000545347
F5H1M3 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 53 aa
5.6 kDa 		No 0
TIAM2-014
ENSP00000437435
ENST00000538270
F5H6R0 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 85 aa
9.1 kDa 		No 0
TIAM2-015
ENSP00000443546
ENST00000535231
A0A0E3D6M9 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 54 aa
5.7 kDa 		No 0
TIAM2-017
ENSP00000442989
ENST00000535583
F5H6W6 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 195 aa
20.9 kDa 		No 0
TIAM2-018
ENSP00000431269
ENST00000462408
H7C5V6 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 156 aa
18 kDa 		No 0
TIAM2-201
ENSP00000327315
ENST00000318981
Q8IVF5 [Direct mapping]
T-lymphoma invasion and metastasis-inducing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1701 aa
190.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.