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WTAP

GENERAL INFORMATION

Gene name

 WTAP

Gene description

 Wilms tumor 1 associated protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA010550
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and ovarian cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA010550

GENE INFORMATION

Gene name

 WTAP (HGNC Symbol)

Synonyms

 KIAA0105, MGC3925, Mum2

Description

 Wilms tumor 1 associated protein (HGNC Symbol)

Entrez gene summary

 The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 q25.3

Chromosome location (bp)

 159725585 - 159756319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146457 (version 83.38)

Entrez gene

 9589

UniProt

 Q15007 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15007

Antibodypedia

 WTAP antibodies

PROTEIN BROWSER
WTAP-001
WTAP-002
WTAP-005
WTAP-201
WTAP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WTAP-001
ENSP00000351141
ENST00000358372
Q15007 [Direct mapping]
Pre-mRNA-splicing regulator WTAP
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0007049 [cell cycle]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031965 [nuclear membrane]
GO:0036396 [MIS complex]
GO:0080009 [mRNA methylation]
Show all
 396 aa
44.2 kDa 		No 0
WTAP-002
ENSP00000336911
ENST00000337387
Q15007 [Direct mapping]
Pre-mRNA-splicing regulator WTAP
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0007049 [cell cycle]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031965 [nuclear membrane]
GO:0036396 [MIS complex]
GO:0080009 [mRNA methylation]
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 151 aa
17.8 kDa 		No 0
WTAP-005
ENSP00000487338
ENST00000631126
A0A087X1R4 [Direct mapping]
Pre-mRNA-splicing regulator WTAP; Wilms tumor 1 associated protein, isoform CRA_f
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
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 170 aa
19.9 kDa 		No 0
WTAP-201
ENSP00000484404
ENST00000614346
A0A087X1R4 [Direct mapping]
Pre-mRNA-splicing regulator WTAP; Wilms tumor 1 associated protein, isoform CRA_f
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
Show all
 170 aa
19.9 kDa 		No 0
WTAP-202
ENSP00000479438
ENST00000621533
Q15007 [Direct mapping]
Pre-mRNA-splicing regulator WTAP
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0007049 [cell cycle]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031965 [nuclear membrane]
GO:0036396 [MIS complex]
GO:0080009 [mRNA methylation]
Show all
 396 aa
44.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.