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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

VIP

Gene description

Vasoactive intestinal peptide

Protein class

Cancer-related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)
HPA (cell line):Cell line enhanced (SH-SY5Y, TIME)
HPA (normal tissue):Group enriched (appendix, colon, rectum, small intestine, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in pancreatic islets cells and nerve ganglion.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 2 antibodies.
HPA017324 , CAB018649
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY

HPA017324
CAB018649

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal carcinomas exhibited moderate membranous staining. Malignant gliomas showed moderate cytoplasmic positivity. A single case of malignant carcinoid was strongly stained. Remaining malignant cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Thyroid cancers and several cases of for example colorectal, ovarian and endometrial cancers exhibited moderate cytoplasmic immunoreactivity. The remaining tumors were weakly stained or negative.

GENE INFORMATION

Gene name

VIP

Synonyms

Description

Vasoactive intestinal peptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]

Chromosome

6

Cytoband

q25.2

Chromosome location (bp)

152750798 - 152759765

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146469 (version 83.38)

Entrez gene

7432

UniProt

P01282 (UniProt - Evidence at protein level)

neXtProt

NX_P01282

Antibodypedia

VIP antibodies

PROTEIN BROWSER

VIP-001
VIP-002
VIP-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VIP-001
ENSP00000356213
ENST00000367244
P01282 [Direct mapping]
VIP peptides Intestinal peptide PHV-42 Intestinal peptide PHM-27 Vasoactive intestinal peptide
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005623 [cell]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007589 [body fluid secretion]
GO:0007611 [learning or memory]
GO:0008284 [positive regulation of cell proliferation]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0032880 [regulation of protein localization]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045909 [positive regulation of vasodilation]
GO:0048255 [mRNA stabilization]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051930 [regulation of sensory perception of pain]
GO:0060406 [positive regulation of penile erection]
GO:0070459 [prolactin secretion]
Show all
170 aa
19.2 kDa
Yes 0
VIP-002
ENSP00000356212
ENST00000367243
P01282 [Direct mapping]
VIP peptides Intestinal peptide PHV-42 Intestinal peptide PHM-27 Vasoactive intestinal peptide
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005623 [cell]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007589 [body fluid secretion]
GO:0008284 [positive regulation of cell proliferation]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0032880 [regulation of protein localization]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0048255 [mRNA stabilization]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070459 [prolactin secretion]
Show all
169 aa
19.1 kDa
Yes 0
VIP-003
ENSP00000410356
ENST00000431366
H0Y763 [Direct mapping]
VIP peptides
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005623 [cell]
GO:0048255 [mRNA stabilization]
GO:0070459 [prolactin secretion]
Show all
119 aa
13.4 kDa
No 0

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