Expression of CCZ1B in cancer - Summary - The Human Protein Atlas

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CCZ1B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCZ1B
Gene description	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA045114 , HPA050006
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045114	HPA050006

GENE INFORMATION
Gene name	CCZ1B (HGNC Symbol)
Synonyms	C7orf28B, DKFZP586I1023, H_NH0577018.2, MGC19819
Description	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p22.1
Chromosome location (bp)	6794134 - 6826770
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146574 (version 83.38)
Entrez gene	221960
UniProt	P86790 (UniProt - Evidence at protein level)
neXtProt	NX_P86790
Antibodypedia	CCZ1B antibodies

PROTEIN BROWSER

CCZ1B-001	CCZ1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCZ1B-001 ENSP00000314544 ENST00000316731	P86790 [Direct mapping] Vacuolar fusion protein CCZ1 homolog B Show all	Predicted intracellular proteins Show all	GO:0005765 [lysosomal membrane] GO:0016192 [vesicle-mediated transport] GO:0031988 [membrane-bounded vesicle] GO:0043231 [intracellular membrane-bounded organelle] Show all	482 aa 55.9 kDa	No	0
CCZ1B-201 ENSP00000487253 ENST00000626257	F8WD66 [Direct mapping] Vacuolar fusion protein CCZ1 homolog; Vacuolar fusion protein CCZ1 homolog B Show all	Predicted intracellular proteins Show all	GO:0016192 [vesicle-mediated transport] GO:0031988 [membrane-bounded vesicle] GO:0043231 [intracellular membrane-bounded organelle] Show all	78 aa 8.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.