Expression of SSC4D in cancer - Summary - The Human Protein Atlas

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SSC4D

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SSC4D
Gene description	Scavenger receptor cysteine rich family, 4 domains
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (EFO-21, Hep G2, U-2 OS)
HPA (normal tissue):	Group enriched (kidney, parathyroid gland, thyroid gland)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA062611
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), renal cancer (unfavourable) and glioma (unfavourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062611

GENE INFORMATION
Gene name	SSC4D (HGNC Symbol)
Synonyms	S4D-SRCRB, SRCRB-S4D, SRCRB4D
Description	Scavenger receptor cysteine rich family, 4 domains (HGNC Symbol)
Entrez gene summary	The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.[supplied by OMIM, Apr 2004]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	76389334 - 76409695
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000146700 (version 83.38)
Entrez gene	136853
UniProt	Q8WTU2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WTU2
Antibodypedia	SSC4D antibodies

PROTEIN BROWSER

SSC4D-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSC4D-001 ENSP00000275560 ENST00000275560	Q8WTU2 [Direct mapping] Scavenger receptor cysteine-rich domain-containing group B protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	575 aa 60.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.