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CCT6A

GENERAL INFORMATION

Gene name

 CCT6A

Gene description

 Chaperonin containing TCP1, subunit 6A (zeta 1)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA042996 , HPA045576 , HPA049949
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), breast cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Breast cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042996
HPA045576
HPA049949

GENE INFORMATION

Gene name

 CCT6A (HGNC Symbol)

Synonyms

 CCT6, Cctz, HTR3, TCP20, TCPZ, TTCP20

Description

 Chaperonin containing TCP1, subunit 6A (zeta 1) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

Chromosome

 7

Cytoband

 p11.2

Chromosome location (bp)

 56051630 - 56063989

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146731 (version 83.38)

Entrez gene

 908

UniProt

 P40227 (UniProt - Evidence at protein level)

neXtProt

 NX_P40227

Antibodypedia

 CCT6A antibodies

PROTEIN BROWSER
CCT6A-001
CCT6A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCT6A-001
ENSP00000275603
ENST00000275603
P40227 [Direct mapping]
T-complex protein 1 subunit zeta
A0A024RDL1 [Target identity:100%; Query identity:100%]
Chaperonin containing TCP1, subunit 6A (Zeta 1), isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
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 531 aa
58 kDa 		No 0
CCT6A-003
ENSP00000352019
ENST00000335503
P40227 [Direct mapping]
T-complex protein 1 subunit zeta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
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 486 aa
53.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.