Expression of TMEM168 in cancer - Summary - The Human Protein Atlas

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TMEM168

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM168
Gene description	Transmembrane protein 168
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA020389
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020389

GENE INFORMATION
Gene name	TMEM168 (HGNC Symbol)
Synonyms	DKFZp564C012, FLJ13576
Description	Transmembrane protein 168 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	112762382 - 112790592
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146802 (version 83.38)
Entrez gene	64418
UniProt	Q9H0V1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H0V1
Antibodypedia	TMEM168 antibodies

PROTEIN BROWSER

TMEM168-001	TMEM168-002	TMEM168-003	TMEM168-004	TMEM168-005	TMEM168-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM168-001 ENSP00000323068 ENST00000312814	Q9H0V1 [Direct mapping] Transmembrane protein 168 A0A024R716 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] Show all	697 aa 79.8 kDa	No	>9
TMEM168-002 ENSP00000390696 ENST00000454074	Q9H0V1 [Direct mapping] Transmembrane protein 168 A0A024R716 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] Show all	697 aa 79.8 kDa	No	>9
TMEM168-003 ENSP00000410307 ENST00000447395	Q9H0V1 [Direct mapping] Transmembrane protein 168 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] Show all	313 aa 35.6 kDa	No	0
TMEM168-004 ENSP00000412462 ENST00000441474	C9IZT1 [Direct mapping] Transmembrane protein 168 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12.4 kDa	Yes	0
TMEM168-005 ENSP00000407373 ENST00000449743	C9JVE9 [Direct mapping] Transmembrane protein 168 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.8 kDa	No	0
TMEM168-007 ENSP00000404253 ENST00000418785	H7C268 [Direct mapping] Transmembrane protein 168 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		258 aa 29.1 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.