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TRIM4

GENERAL INFORMATION

Gene name

 TRIM4

Gene description

 Tripartite motif containing 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA019356 , HPA029461
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019356
HPA029461

GENE INFORMATION

Gene name

 TRIM4 (HGNC Symbol)

Synonyms

 RNF87

Description

 Tripartite motif containing 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 99876958 - 99919600

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146833 (version 83.38)

Entrez gene

 89122

UniProt

 Q9C037 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C037

Antibodypedia

 TRIM4 antibodies

PROTEIN BROWSER
TRIM4-001
TRIM4-002
TRIM4-004
TRIM4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM4-001
ENSP00000275736
ENST00000349062
Q9C037 [Direct mapping]
E3 ubiquitin-protein ligase TRIM4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0045087 [innate immune response]
GO:0070206 [protein trimerization]
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 474 aa
54.2 kDa 		No 0
TRIM4-002
ENSP00000396229
ENST00000447480
H7C0Q6 [Direct mapping]
E3 ubiquitin-protein ligase TRIM4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
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 202 aa
23.4 kDa 		No 0
TRIM4-004
ENSP00000348216
ENST00000355947
Q9C037 [Direct mapping]
E3 ubiquitin-protein ligase TRIM4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0045087 [innate immune response]
GO:0070206 [protein trimerization]
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 500 aa
57.5 kDa 		No 0
TRIM4-005
ENSP00000346186
ENST00000354241
Q9C037 [Direct mapping]
E3 ubiquitin-protein ligase TRIM4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0045087 [innate immune response]
GO:0070206 [protein trimerization]
Show all
 294 aa
34.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.