Fields »
ABOUT
HELP
BLOG
MEPCE

GENERAL INFORMATION

Gene name

 MEPCE

Gene description

 Methylphosphate capping enzyme

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA051587 , CAB026384
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051587
CAB026384

GENE INFORMATION

Gene name

 MEPCE (HGNC Symbol)

Synonyms

 BCDIN3, FLJ20257, MePCE

Description

 Methylphosphate capping enzyme (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100428790 - 100434126

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146834 (version 83.38)

Entrez gene

 56257

UniProt

 Q7L2J0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L2J0

Antibodypedia

 MEPCE antibodies

PROTEIN BROWSER
MEPCE-001
MEPCE-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEPCE-001
ENSP00000308546
ENST00000310512
Q7L2J0 [Direct mapping]
7SK snRNA methylphosphate capping enzyme
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001510 [RNA methylation]
GO:0008168 [methyltransferase activity]
GO:0008173 [RNA methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016073 [snRNA metabolic process]
GO:0035562 [negative regulation of chromatin binding]
GO:0040031 [snRNA modification]
GO:0044822 [poly(A) RNA binding]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
Show all
 689 aa
74.4 kDa 		No 0
MEPCE-002
ENSP00000400875
ENST00000414441
Q7L2J0 [Direct mapping]
7SK snRNA methylphosphate capping enzyme
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001510 [RNA methylation]
GO:0008168 [methyltransferase activity]
GO:0008173 [RNA methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016073 [snRNA metabolic process]
GO:0040031 [snRNA modification]
GO:0044822 [poly(A) RNA binding]
Show all
 220 aa
24.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.