Expression of NOM1 in cancer - Summary - The Human Protein Atlas

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NOM1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NOM1
Gene description	Nucleolar protein with MIF4G domain 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019866
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019866

GENE INFORMATION
Gene name	NOM1 (HGNC Symbol)
Synonyms	C7orf3, PPP1R113, SGD1
Description	Nucleolar protein with MIF4G domain 1 (HGNC Symbol)
Entrez gene summary	Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	q36.3
Chromosome location (bp)	156949723 - 156973182
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146909 (version 83.38)
Entrez gene	64434
UniProt	Q5C9Z4 (UniProt - Evidence at protein level)
neXtProt	NX_Q5C9Z4
Antibodypedia	NOM1 antibodies

PROTEIN BROWSER

NOM1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOM1-001 ENSP00000275820 ENST00000275820	Q5C9Z4 [Direct mapping] Nucleolar MIF4G domain-containing protein 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0008150 [biological_process] GO:0022008 [neurogenesis] GO:0042274 [ribosomal small subunit biogenesis] GO:0044822 [poly(A) RNA binding] Show all	860 aa 96.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.