Fields »
ABOUT
HELP
BLOG
NCAPG2

GENERAL INFORMATION

Gene name

 NCAPG2

Gene description

 Non-SMC condensin II complex, subunit G2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA026631
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), head and neck cancer (favourable), melanoma (unfavourable), endometrial cancer (unfavourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
Melanoma p<0.001
Endometrial cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026631

GENE INFORMATION

Gene name

 NCAPG2 (HGNC Symbol)

Synonyms

 CAP-G2, FLJ20311, hCAP-G2, LUZP5, MTB

Description

 Non-SMC condensin II complex, subunit G2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 7

Cytoband

 q36.3

Chromosome location (bp)

 158631311 - 158704829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146918 (version 83.38)

Entrez gene

 54892

UniProt

 Q86XI2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86XI2

Antibodypedia

 NCAPG2 antibodies

PROTEIN BROWSER
NCAPG2-001
NCAPG2-003
NCAPG2-004
NCAPG2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCAPG2-001
ENSP00000348657
ENST00000356309
Q86XI2 [Direct mapping]
Condensin-2 complex subunit G2
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0007067 [mitotic nuclear division]
GO:0016020 [membrane]
GO:0030261 [chromosome condensation]
GO:0035064 [methylated histone binding]
GO:0051301 [cell division]
Show all
 1143 aa
131 kDa 		No 0
NCAPG2-003
ENSP00000387007
ENST00000409339
Q86XI2 [Direct mapping]
Condensin-2 complex subunit G2
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0001833 [inner cell mass cell proliferation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0007067 [mitotic nuclear division]
GO:0016020 [membrane]
GO:0030261 [chromosome condensation]
GO:0035064 [methylated histone binding]
GO:0051301 [cell division]
Show all
 1156 aa
132.2 kDa 		No 0
NCAPG2-004
ENSP00000386569
ENST00000409423
Q86XI2 [Direct mapping]
Condensin-2 complex subunit G2
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0007067 [mitotic nuclear division]
GO:0016020 [membrane]
GO:0030261 [chromosome condensation]
GO:0035064 [methylated histone binding]
GO:0051301 [cell division]
Show all
 1143 aa
131 kDa 		No 0
NCAPG2-007
ENSP00000408080
ENST00000441982
H0Y6U5 [Direct mapping]
Condensin-2 complex subunit G2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005634 [nucleus]
Show all
 898 aa
102.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.