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Most of the malignant cells displayed weak to moderate cytoplasmic immunoreactivity with additional nuclear staining in a few cases. Testicular cancers displayed additional membranous staining in several cases. Many malignant lymphomas along with several stomach and pancreatic cancers were negative.
GENE INFORMATION
Gene name
SHROOM2 (HGNC Symbol)
Synonyms
APXL
Description
Shroom family member 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome. [provided by RefSeq, Jul 2008]