Expression of DENND2A in cancer - Summary - The Human Protein Atlas

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DENND2A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DENND2A
Gene description	DENN/MADD domain containing 2A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (AF22, BJ hTERT+, RPTEC TERT1, U-2197)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA021778 , HPA026718
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), glioma (unfavourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Glioma p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021778	HPA026718

GENE INFORMATION
Gene name	DENND2A (HGNC Symbol)
Synonyms	FAM31D, KIAA1277
Description	DENN/MADD domain containing 2A (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q34
Chromosome location (bp)	140518420 - 140673993
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146966 (version 83.38)
Entrez gene	27147
UniProt	Q9ULE3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9ULE3
Antibodypedia	DENND2A antibodies

PROTEIN BROWSER

DENND2A-001	DENND2A-002	DENND2A-003	DENND2A-006	DENND2A-007	DENND2A-008	DENND2A-009	DENND2A-010	DENND2A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND2A-001 ENSP00000275884 ENST00000275884	Q9ULE3 [Direct mapping] DENN domain-containing protein 2A Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0015031 [protein transport] GO:0015629 [actin cytoskeleton] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043547 [positive regulation of GTPase activity] Show all	1009 aa 113.9 kDa	No	0
DENND2A-002 ENSP00000419654 ENST00000496613	Q9ULE3 [Direct mapping] DENN domain-containing protein 2A Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0015031 [protein transport] GO:0015629 [actin cytoskeleton] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043547 [positive regulation of GTPase activity] Show all	1009 aa 113.9 kDa	No	0
DENND2A-003 ENSP00000419464 ENST00000492720	Q9ULE3 [Direct mapping] DENN domain-containing protein 2A Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0015031 [protein transport] GO:0015629 [actin cytoskeleton] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043547 [positive regulation of GTPase activity] Show all	795 aa 89.5 kDa	No	0
DENND2A-006 ENSP00000420605 ENST00000475837	C9JD15 [Direct mapping] DENN domain-containing protein 2A Show all	Predicted intracellular proteins Show all		105 aa 11.8 kDa	No	0
DENND2A-007 ENSP00000418088 ENST00000489552	C9JAA0 [Direct mapping] DENN domain-containing protein 2A Show all	Predicted intracellular proteins Show all		90 aa 10 kDa	No	0
DENND2A-008 ENSP00000418760 ENST00000477488	C9IYZ8 [Direct mapping] DENN domain-containing protein 2A Show all	Predicted intracellular proteins Show all		79 aa 8.8 kDa	No	0
DENND2A-009 ENSP00000418844 ENST00000491728	C9IY76 [Direct mapping] DENN domain-containing protein 2A Show all	Predicted intracellular proteins Show all		158 aa 17.5 kDa	No	0
DENND2A-010 ENSP00000420145 ENST00000469373	H7C5K8 [Direct mapping] DENN domain-containing protein 2A Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		163 aa 18.1 kDa	No	0
DENND2A-201 ENSP00000442245 ENST00000537639	Q9ULE3 [Direct mapping] DENN domain-containing protein 2A Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0015031 [protein transport] GO:0015629 [actin cytoskeleton] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043547 [positive regulation of GTPase activity] Show all	1009 aa 113.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.