Fields »
ABOUT
HELP
BLOG
CASK

GENERAL INFORMATION

Gene name

 CASK

Gene description

 Calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA023857 , CAB001949
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CASK (HGNC Symbol)

Synonyms

 CAGH39, FGS4, LIN2, TNRC8

Description

 Calcium/calmodulin-dependent serine protein kinase (MAGUK family) (HGNC Symbol)

Entrez gene summary

 This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 p11.4

Chromosome location (bp)

 41514934 - 41923463

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147044 (version 83.38)

Entrez gene

 8573

UniProt

 O14936 (UniProt - Evidence at protein level)

neXtProt

 NX_O14936

Antibodypedia

 CASK antibodies

PROTEIN BROWSER
CASK-001
CASK-002
CASK-004
CASK-005
CASK-006
CASK-007
CASK-012
CASK-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASK-001
ENSP00000367400
ENST00000378158
O14936 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004385 [guanylate kinase activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005604 [basement membrane]
GO:0005652 [nuclear lamina]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030198 [extracellular matrix organization]
GO:0042734 [presynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0060170 [ciliary membrane]
GO:0061045 [negative regulation of wound healing]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
 909 aa
103.2 kDa 		No 1
CASK-002
ENSP00000367421
ENST00000378179
Q5JS72 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 518 aa
59.4 kDa 		No 0
CASK-004
ENSP00000400526
ENST00000421587
O14936 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004385 [guanylate kinase activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005604 [basement membrane]
GO:0005652 [nuclear lamina]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030198 [extracellular matrix organization]
GO:0042734 [presynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0060170 [ciliary membrane]
GO:0061045 [negative regulation of wound healing]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
 897 aa
102.1 kDa 		No 1
CASK-005
ENSP00000367408
ENST00000378166
O14936 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004385 [guanylate kinase activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005604 [basement membrane]
GO:0005634 [nucleus]
GO:0005652 [nuclear lamina]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016363 [nuclear matrix]
GO:0030198 [extracellular matrix organization]
GO:0031982 [vesicle]
GO:0042043 [neurexin family protein binding]
GO:0042734 [presynaptic membrane]
GO:0045202 [synapse]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0060170 [ciliary membrane]
GO:0061045 [negative regulation of wound healing]
GO:0070509 [calcium ion import]
GO:0090280 [positive regulation of calcium ion import]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
 921 aa
104.5 kDa 		No 1
CASK-006
ENSP00000367396
ENST00000378154
Q5JS74 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 590 aa
66.6 kDa 		No 1
CASK-007
ENSP00000367405
ENST00000378163
O14936 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004385 [guanylate kinase activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005604 [basement membrane]
GO:0005652 [nuclear lamina]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030198 [extracellular matrix organization]
GO:0042734 [presynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0060170 [ciliary membrane]
GO:0061045 [negative regulation of wound healing]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
 926 aa
105.1 kDa 		No 1
CASK-012
ENSP00000367410
ENST00000378168
Q5JS79 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 381 aa
43.7 kDa 		No 0
CASK-013
ENSP00000398007
ENST00000442742
O14936 [Direct mapping]
Peripheral plasma membrane protein CASK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0004385 [guanylate kinase activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005604 [basement membrane]
GO:0005652 [nuclear lamina]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030198 [extracellular matrix organization]
GO:0042734 [presynaptic membrane]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0060170 [ciliary membrane]
GO:0061045 [negative regulation of wound healing]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
 898 aa
102.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.