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HDAC8

GENERAL INFORMATION

Gene name

 HDAC8

Gene description

 Histone deacetylase 8

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA048560
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048560

GENE INFORMATION

Gene name

 HDAC8 (HGNC Symbol)

Synonyms

 HDACL1, MRXS6, RPD3, WTS

Description

 Histone deacetylase 8 (HGNC Symbol)

Entrez gene summary

 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 72329516 - 72573103

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147099 (version 83.38)

Entrez gene

 55869

UniProt

 Q9BY41 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BY41

Antibodypedia

 HDAC8 antibodies

PROTEIN BROWSER
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HDAC8-001
HDAC8-002
HDAC8-003
HDAC8-004
HDAC8-005
HDAC8-006
HDAC8-007
HDAC8-008
HDAC8-009
HDAC8-010
HDAC8-012
HDAC8-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC8-001
ENSP00000362674
ENST00000373573
Q9BY41 [Direct mapping]
Histone deacetylase 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0007062 [sister chromatid cohesion]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0046872 [metal ion binding]
GO:0070932 [histone H3 deacetylation]
GO:0071922 [regulation of cohesin localization to chromatin]
Show all
 377 aa
41.8 kDa 		No 0
HDAC8-002
ENSP00000414486
ENST00000439122
Q9BY41 [Direct mapping]
Histone deacetylase 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0007062 [sister chromatid cohesion]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0046872 [metal ion binding]
GO:0070932 [histone H3 deacetylation]
GO:0071922 [regulation of cohesin localization to chromatin]
Show all
 256 aa
28.4 kDa 		No 0
HDAC8-003
ENSP00000362657
ENST00000373556
Q9BY41 [Direct mapping]
Histone deacetylase 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0007062 [sister chromatid cohesion]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0046872 [metal ion binding]
GO:0070932 [histone H3 deacetylation]
GO:0071922 [regulation of cohesin localization to chromatin]
Show all
 158 aa
17.4 kDa 		No 0
HDAC8-004
ENSP00000362672
ENST00000373571
A6NMT1 [Direct mapping]
Histone deacetylase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 253 aa
28.1 kDa 		No 0
HDAC8-005
ENSP00000362655
ENST00000373554
Q9BY41 [Direct mapping]
Histone deacetylase 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0007062 [sister chromatid cohesion]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0046872 [metal ion binding]
GO:0070932 [histone H3 deacetylation]
GO:0071922 [regulation of cohesin localization to chromatin]
Show all
 146 aa
16.1 kDa 		No 0
HDAC8-006
ENSP00000362669
ENST00000373568
A6NGJ7 [Direct mapping]
Histone deacetylase 8
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
Show all
 248 aa
27.5 kDa 		No 0
HDAC8-007
ENSP00000362661
ENST00000373560
A6NGT0 [Direct mapping]
Histone deacetylase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 156 aa
17.1 kDa 		No 0
HDAC8-008
ENSP00000362660
ENST00000373559
Q9BY41 [Direct mapping]
Histone deacetylase 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0007062 [sister chromatid cohesion]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0046872 [metal ion binding]
GO:0070932 [histone H3 deacetylation]
GO:0071922 [regulation of cohesin localization to chromatin]
Show all
 139 aa
15.7 kDa 		No 0
HDAC8-009
ENSP00000398997
ENST00000421523
C9J8F0 [Direct mapping]
Histone deacetylase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 132 aa
14.7 kDa 		No 0
HDAC8-010
ENSP00000362685
ENST00000373583
A6NFW1 [Direct mapping]
Histone deacetylase 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
7.3 kDa 		No 0
HDAC8-012
ENSP00000396424
ENST00000415409
E7EVA8 [Direct mapping]
Histone deacetylase 8
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0016575 [histone deacetylation]
Show all
 299 aa
32.9 kDa 		No 0
HDAC8-201
ENSP00000362691
ENST00000373589
Q9BY41 [Direct mapping]
Histone deacetylase 8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0007062 [sister chromatid cohesion]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0046872 [metal ion binding]
GO:0070932 [histone H3 deacetylation]
GO:0071922 [regulation of cohesin localization to chromatin]
Show all
 286 aa
31.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.