Expression of AWAT2 in cancer - Summary - The Human Protein Atlas

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AWAT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AWAT2
Gene description	Acyl-CoA wax alcohol acyltransferase 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (breast, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in sebaceous glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA062748
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062748

GENE INFORMATION
Gene name	AWAT2 (HGNC Symbol)
Synonyms	DGAT2L4, MFAT
Description	Acyl-CoA wax alcohol acyltransferase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q13.1
Chromosome location (bp)	70040542 - 70049938
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147160 (version 83.38)
Entrez gene	158835
UniProt	Q6E213 (UniProt - Evidence at protein level)
neXtProt	NX_Q6E213
Antibodypedia	AWAT2 antibodies

PROTEIN BROWSER

AWAT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AWAT2-001 ENSP00000421172 ENST00000276101	Q6E213 [Direct mapping] Acyl-CoA wax alcohol acyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0042572 [retinol metabolic process] GO:0047196 [long-chain-alcohol O-fatty-acyltransferase activity] GO:0050252 [retinol O-fatty-acyltransferase activity] Show all	333 aa 38.1 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.