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Several hepatocellular carcinomas, renal cell carcinomas along with a few cases of gliomas, lymphomas and thyroid cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were in general weakly stained or negative.
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000123 [histone acetyltransferase complex] GO:0000791 [euchromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006041 [glucosamine metabolic process] GO:0006110 [regulation of glycolytic process] GO:0006325 [chromatin organization] GO:0006493 [protein O-linked glycosylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007584 [response to nutrient] GO:0008047 [enzyme activator activity] GO:0008134 [transcription factor binding] GO:0008375 [acetylglucosaminyltransferase activity] GO:0010628 [positive regulation of gene expression] GO:0010801 [negative regulation of peptidyl-threonine phosphorylation] GO:0016262 [protein N-acetylglucosaminyltransferase activity] GO:0019904 [protein domain specific binding] GO:0030854 [positive regulation of granulocyte differentiation] GO:0030900 [forebrain development] GO:0031397 [negative regulation of protein ubiquitination] GO:0032868 [response to insulin] GO:0032869 [cellular response to insulin stimulus] GO:0032922 [circadian regulation of gene expression] GO:0033137 [negative regulation of peptidyl-serine phosphorylation] GO:0035020 [regulation of Rac protein signal transduction] GO:0042277 [peptide binding] GO:0042588 [zymogen granule] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043085 [positive regulation of catalytic activity] GO:0043981 [histone H4-K5 acetylation] GO:0043982 [histone H4-K8 acetylation] GO:0043984 [histone H4-K16 acetylation] GO:0043995 [histone acetyltransferase activity (H4-K5 specific)] GO:0043996 [histone acetyltransferase activity (H4-K8 specific)] GO:0045793 [positive regulation of cell size] GO:0045862 [positive regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046626 [regulation of insulin receptor signaling pathway] GO:0046972 [histone acetyltransferase activity (H4-K16 specific)] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048029 [monosaccharide binding] GO:0048312 [intracellular distribution of mitochondria] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0060548 [negative regulation of cell death] GO:0061087 [positive regulation of histone H3-K27 methylation] GO:0070207 [protein homotrimerization] GO:0070208 [protein heterotrimerization] GO:0070688 [MLL5-L complex] GO:0071222 [cellular response to lipopolysaccharide] GO:0071300 [cellular response to retinoic acid] GO:0071333 [cellular response to glucose stimulus] GO:0080182 [histone H3-K4 trimethylation] GO:0090315 [negative regulation of protein targeting to membrane] GO:0090526 [regulation of gluconeogenesis involved in cellular glucose homeostasis] GO:0097237 [cellular response to toxic substance] GO:0097363 [protein O-GlcNAc transferase activity] GO:1900038 [negative regulation of cellular response to hypoxia] GO:1900182 [positive regulation of protein localization to nucleus] GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex] GO:0005515 [protein binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006110 [regulation of glycolytic process] GO:0006325 [chromatin organization] GO:0006493 [protein O-linked glycosylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007584 [response to nutrient] GO:0008047 [enzyme activator activity] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016262 [protein N-acetylglucosaminyltransferase activity] GO:0030854 [positive regulation of granulocyte differentiation] GO:0031397 [negative regulation of protein ubiquitination] GO:0032868 [response to insulin] GO:0032922 [circadian regulation of gene expression] GO:0035020 [regulation of Rac protein signal transduction] GO:0043085 [positive regulation of catalytic activity] GO:0043981 [histone H4-K5 acetylation] GO:0043982 [histone H4-K8 acetylation] GO:0043984 [histone H4-K16 acetylation] GO:0043995 [histone acetyltransferase activity (H4-K5 specific)] GO:0043996 [histone acetyltransferase activity (H4-K8 specific)] GO:0045862 [positive regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046626 [regulation of insulin receptor signaling pathway] GO:0046972 [histone acetyltransferase activity (H4-K16 specific)] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0061087 [positive regulation of histone H3-K27 methylation] GO:0070688 [MLL5-L complex] GO:0071300 [cellular response to retinoic acid] GO:0080182 [histone H3-K4 trimethylation] GO:0090526 [regulation of gluconeogenesis involved in cellular glucose homeostasis] GO:0097363 [protein O-GlcNAc transferase activity]