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IL2RG

GENERAL INFORMATION

Gene name

 IL2RG

Gene description

 Interleukin 2 receptor, gamma

Protein class

 Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Tissue enhanced (small intestine, spleen)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 High cytoplasmic expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA046641
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IL2RG (HGNC Symbol)

Synonyms

 CD132, CIDX, IMD4, SCIDX1

Description

 Interleukin 2 receptor, gamma (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 71107404 - 71112108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147168 (version 83.38)

Entrez gene

 3561

UniProt

 P31785 (UniProt - Evidence at protein level)

neXtProt

 NX_P31785

Antibodypedia

 IL2RG antibodies

PROTEIN BROWSER
IL2RG-001
IL2RG-002
IL2RG-003
IL2RG-004
IL2RG-005
IL2RG-201
IL2RG-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL2RG-001
ENSP00000423966
ENST00000487883
D6RBW5 [Direct mapping]
Cytokine receptor common subunit gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 176 aa
20.8 kDa 		No 0
IL2RG-002
ENSP00000423601
ENST00000473378
D6R964 [Direct mapping]
Cytokine receptor common subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 99 aa
11.2 kDa 		No 0
IL2RG-003
ENSP00000421262
ENST00000482750
H0Y8J6 [Direct mapping]
Cytokine receptor common subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 65 aa
7.6 kDa 		No 0
IL2RG-004
ENSP00000363318
ENST00000374202
P31785 [Direct mapping]
Cytokine receptor common subunit gamma
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004911 [interleukin-2 receptor activity]
GO:0004913 [interleukin-4 receptor activity]
GO:0004917 [interleukin-7 receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019976 [interleukin-2 binding]
GO:0019982 [interleukin-7 binding]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0038111 [interleukin-7-mediated signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 369 aa
42.3 kDa 		Yes 1
IL2RG-005
ENSP00000425233
ENST00000464642
D6RDW9 [Direct mapping]
Cytokine receptor common subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 220 aa
26.1 kDa 		No 0
IL2RG-201
ENSP00000363303
ENST00000374188
Q5FC10 [Direct mapping]
Cytokine receptor common subunit gamma; IL2RG nirs variant 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 98 aa
10.8 kDa 		No 0
IL2RG-202
ENSP00000388967
ENST00000456850
P31785 [Direct mapping]
Cytokine receptor common subunit gamma
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004911 [interleukin-2 receptor activity]
GO:0004913 [interleukin-4 receptor activity]
GO:0004917 [interleukin-7 receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019976 [interleukin-2 binding]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0038111 [interleukin-7-mediated signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 179 aa
20.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.