Expression of DIAPH2 in cancer - Summary

GENERAL INFORMATION
Gene name	DIAPH2
Gene description	Diaphanous-related formin 2
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, most abundant in testis, fallopian tube, endometrium and the large intestines.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA005647 , CAB015461 , CAB068183 , CAB068184
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005647	CAB015461	CAB068183	CAB068184

GENE INFORMATION
Gene name	DIAPH2 (HGNC Symbol)
Synonyms	DIA, DIA2, POF, POF2
Description	Diaphanous-related formin 2 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q21.33
Chromosome location (bp)	96684663 - 97604997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147202 (version 83.38)
Entrez gene	1730
UniProt	O60879 (UniProt - Evidence at protein level)
neXtProt	NX_O60879
Antibodypedia	DIAPH2 antibodies

PROTEIN BROWSER

DIAPH2-001	DIAPH2-002	DIAPH2-201	DIAPH2-202	DIAPH2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DIAPH2-001 ENSP00000362140 ENST00000373049	O60879 [Direct mapping] Protein diaphanous homolog 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0003779 [actin binding] GO:0005102 [receptor binding] GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005769 [early endosome] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007275 [multicellular organismal development] GO:0007292 [female gamete generation] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0043231 [intracellular membrane-bounded organelle] GO:0048477 [oogenesis] Show all	1096 aa 124.8 kDa	No	0
DIAPH2-002 ENSP00000321348 ENST00000324765	O60879 [Direct mapping] Protein diaphanous homolog 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0003779 [actin binding] GO:0005102 [receptor binding] GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005769 [early endosome] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007275 [multicellular organismal development] GO:0007292 [female gamete generation] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0030041 [actin filament polymerization] GO:0043231 [intracellular membrane-bounded organelle] GO:0048477 [oogenesis] Show all	1101 aa 125.6 kDa	No	0
DIAPH2-201 ENSP00000348082 ENST00000355827	A6NML8 [Direct mapping] Diaphanous homolog 2 (Drosophila), isoform CRA_c; Protein diaphanous homolog 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0007015 [actin filament organization] GO:0007292 [female gamete generation] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0043231 [intracellular membrane-bounded organelle] Show all	1096 aa 124.9 kDa	No	0
DIAPH2-202 ENSP00000362145 ENST00000373054	C9J6U3 [Direct mapping] Protein diaphanous homolog 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0007015 [actin filament organization] GO:0007292 [female gamete generation] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0043231 [intracellular membrane-bounded organelle] Show all	1103 aa 125.5 kDa	No	0
DIAPH2-203 ENSP00000362152 ENST00000373061	K4DI95 [Direct mapping] Diaphanous homolog 2 (Drosophila), isoform CRA_a; Protein diaphanous homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0007015 [actin filament organization] GO:0007292 [female gamete generation] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0043231 [intracellular membrane-bounded organelle] Show all	1101 aa 125.6 kDa	No	0