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HTR2C

GENERAL INFORMATION

Gene name

 HTR2C

Gene description

 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (EFO-21, U-266/70, U-266/84)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HTR2C (HGNC Symbol)

Synonyms

 5-HT2C, 5HTR2C, HTR1C

Description

 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HGNC Symbol)

Entrez gene summary

 This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 X

Cytoband

 q23

Chromosome location (bp)

 114584078 - 114910061

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147246 (version 83.38)

Entrez gene

 3358

UniProt

 P28335 (UniProt - Evidence at protein level)

neXtProt

 NX_P28335

Antibodypedia

 HTR2C antibodies

PROTEIN BROWSER
HTR2C-001
HTR2C-002
HTR2C-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR2C-001
ENSP00000361019
ENST00000371951
P28335 [Direct mapping]
5-hydroxytryptamine receptor 2C
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001587 [Gq/11-coupled serotonin receptor activity]
GO:0001662 [behavioral fear response]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007208 [phospholipase C-activating serotonin receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0007631 [feeding behavior]
GO:0008144 [drug binding]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0031644 [regulation of neurological system process]
GO:0032098 [regulation of appetite]
GO:0042493 [response to drug]
GO:0043397 [regulation of corticotropin-releasing hormone secretion]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 458 aa
51.8 kDa 		Yes 7
HTR2C-002
ENSP00000276198
ENST00000276198
P28335 [Direct mapping]
5-hydroxytryptamine receptor 2C
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001587 [Gq/11-coupled serotonin receptor activity]
GO:0001662 [behavioral fear response]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007208 [phospholipase C-activating serotonin receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0007631 [feeding behavior]
GO:0008144 [drug binding]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0031644 [regulation of neurological system process]
GO:0032098 [regulation of appetite]
GO:0042493 [response to drug]
GO:0043397 [regulation of corticotropin-releasing hormone secretion]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 458 aa
51.8 kDa 		Yes 7
HTR2C-003
ENSP00000361018
ENST00000371950
P28335 [Direct mapping]
5-hydroxytryptamine receptor 2C
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001587 [Gq/11-coupled serotonin receptor activity]
GO:0001662 [behavioral fear response]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007208 [phospholipase C-activating serotonin receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0007631 [feeding behavior]
GO:0008144 [drug binding]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0031644 [regulation of neurological system process]
GO:0032098 [regulation of appetite]
GO:0042493 [response to drug]
GO:0043397 [regulation of corticotropin-releasing hormone secretion]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 248 aa
28 kDa 		Yes 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.