Expression of DOCK11 in cancer - Summary - The Human Protein Atlas

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DOCK11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DOCK11
Gene description	Dedicator of cytokinesis 11
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA059695
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059695

GENE INFORMATION
Gene name	DOCK11 (HGNC Symbol)
Synonyms	ACG, FLJ32122, FLJ43653, ZIZ2
Description	Dedicator of cytokinesis 11 (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	q24
Chromosome location (bp)	118495898 - 118686163
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147251 (version 83.38)
Entrez gene	139818
UniProt	Q5JSL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JSL3
Antibodypedia	DOCK11 antibodies

PROTEIN BROWSER

DOCK11-001	DOCK11-003	DOCK11-004	DOCK11-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOCK11-001 ENSP00000276204 ENST00000276204	A6NIW2 [Direct mapping] Dedicator of cytokinesis protein 11 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	2077 aa 238.1 kDa	No	0
DOCK11-003 ENSP00000276202 ENST00000276202	Q5JSL3 [Direct mapping] Dedicator of cytokinesis protein 11 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0017048 [Rho GTPase binding] GO:0043547 [positive regulation of GTPase activity] Show all	2073 aa 237.7 kDa	No	0
DOCK11-004 ENSP00000488503 ENST00000632573		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.7 kDa	No	0
DOCK11-005 ENSP00000487829 ENST00000633080		MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	1902 aa 218.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.