Expression of ARHGAP36 in cancer - Summary - The Human Protein Atlas

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ARHGAP36

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARHGAP36
Gene description	Rho GTPase activating protein 36
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enriched (SH-SY5Y)
HPA (normal tissue):	Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in pituitary and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with GTEx and HPA RNA expression data.
Reliability score	Supported based on 1 antibody. HPA002064
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002064

GENE INFORMATION
Gene name	ARHGAP36 (HGNC Symbol)
Synonyms	FLJ30058
Description	Rho GTPase activating protein 36 (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	q26.1
Chromosome location (bp)	131058242 - 131089883
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147256 (version 83.38)
Entrez gene	158763
UniProt	Q6ZRI8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZRI8
Antibodypedia	ARHGAP36 antibodies

PROTEIN BROWSER

ARHGAP36-001	ARHGAP36-002	ARHGAP36-003	ARHGAP36-004	ARHGAP36-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP36-001 ENSP00000359959 ENST00000370921	Q6ZRI8 [Direct mapping] Rho GTPase-activating protein 36 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	411 aa 46.2 kDa	No	0
ARHGAP36-002 ENSP00000359960 ENST00000370922	Q6ZRI8 [Direct mapping] Rho GTPase-activating protein 36 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	535 aa 60.6 kDa	No	0
ARHGAP36-003 ENSP00000409218 ENST00000423277	X6RIA0 [Direct mapping] Rho GTPase-activating protein 36 Show all	Predicted intracellular proteins Show all	GO:0007165 [signal transduction] Show all	218 aa 25 kDa	No	0
ARHGAP36-004 ENSP00000408515 ENST00000412432	Q6ZRI8 [Direct mapping] Rho GTPase-activating protein 36 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	516 aa 58.3 kDa	No	0
ARHGAP36-005 ENSP00000276211 ENST00000276211	Q6ZRI8 [Direct mapping] Rho GTPase-activating protein 36 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	547 aa 61.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.