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GPC3

GENERAL INFORMATION

Gene name

 GPC3

Gene description

 Glypican 3

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GPC3 (HGNC Symbol)

Synonyms

 DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1

Description

 Glypican 3 (HGNC Symbol)

Entrez gene summary

 Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Chromosome

 X

Cytoband

 q26.2

Chromosome location (bp)

 133535745 - 133985895

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147257 (version 83.38)

Entrez gene

 2719

UniProt

 P51654 (UniProt - Evidence at protein level)

neXtProt

 NX_P51654

Antibodypedia

 GPC3 antibodies

PROTEIN BROWSER
GPC3-001
GPC3-002
GPC3-003
GPC3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPC3-001
ENSP00000359854
ENST00000370818
P51654 [Direct mapping]
Glypican-3 Secreted glypican-3
I6QTG3 [Target identity:100%; Query identity:100%]
Glypican 3 isoform 2; Glypican 3, isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007603 [phototransduction, visible light]
GO:0009653 [anatomical structure morphogenesis]
GO:0010466 [negative regulation of peptidase activity]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0043202 [lysosomal lumen]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044281 [small molecule metabolic process]
GO:0060422 [peptidyl-dipeptidase inhibitor activity]
GO:0070062 [extracellular exosome]
GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development]
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 580 aa
65.6 kDa 		Yes 1
GPC3-002
ENSP00000385307
ENST00000406757
H0Y3U6 [Direct mapping]
Glypican-3
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0031225 [anchored component of membrane]
GO:0043395 [heparan sulfate proteoglycan binding]
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 256 aa
29 kDa 		No 0
GPC3-003
ENSP00000486325
ENST00000631057
P51654 [Direct mapping]
Glypican-3 Secreted glypican-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007603 [phototransduction, visible light]
GO:0009653 [anatomical structure morphogenesis]
GO:0010466 [negative regulation of peptidase activity]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0043202 [lysosomal lumen]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044281 [small molecule metabolic process]
GO:0060422 [peptidyl-dipeptidase inhibitor activity]
GO:0070062 [extracellular exosome]
GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development]
Show all
 526 aa
59.5 kDa 		Yes 1
GPC3-201
ENSP00000377836
ENST00000394299
P51654 [Direct mapping]
Glypican-3 Secreted glypican-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007603 [phototransduction, visible light]
GO:0008285 [negative regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009948 [anterior/posterior axis specification]
GO:0010171 [body morphogenesis]
GO:0010466 [negative regulation of peptidase activity]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030282 [bone mineralization]
GO:0030316 [osteoclast differentiation]
GO:0030324 [lung development]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0040008 [regulation of growth]
GO:0043202 [lysosomal lumen]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044281 [small molecule metabolic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045807 [positive regulation of endocytosis]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045926 [negative regulation of growth]
GO:0046326 [positive regulation of glucose import]
GO:0046658 [anchored component of plasma membrane]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0060422 [peptidyl-dipeptidase inhibitor activity]
GO:0060976 [coronary vasculature development]
GO:0070062 [extracellular exosome]
GO:0072111 [cell proliferation involved in kidney development]
GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development]
GO:0072180 [mesonephric duct morphogenesis]
GO:0072203 [cell proliferation involved in metanephros development]
Show all
 603 aa
68.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.