Fields »
ABOUT
HELP
BLOG
GPR119

GENERAL INFORMATION

Gene name

 GPR119

Gene description

 G protein-coupled receptor 119

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Cell line enhanced (Hep G2)
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GPR119 (HGNC Symbol)

Synonyms

 GPCR2, hGPCR2

Description

 G protein-coupled receptor 119 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 q26.1

Chromosome location (bp)

 130384440 - 130385447

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147262 (version 83.38)

Entrez gene

 139760

UniProt

 Q8TDV5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDV5

Antibodypedia

 GPR119 antibodies

PROTEIN BROWSER
GPR119-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR119-001
ENSP00000276218
ENST00000276218
Q8TDV5 [Direct mapping]
Glucose-dependent insulinotropic receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Lysolipids receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0030073 [insulin secretion]
GO:0031210 [phosphatidylcholine binding]
GO:0043235 [receptor complex]
Show all
 335 aa
36.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.