Cell atlas - ZNF185 - The Human Protein Atlas

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ZNF185

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol
	Focal adhesion sites
	Plasma membrane

Human cell
	Actin Filaments
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ZNF185
Gene description	Zinc finger protein 185 (LIM domain)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the actin filaments & focal adhesion sites.
RNA cell category	Cell line enhanced (TIME, EFO-21, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cytosol (supported)
Additional location	In addition localized to the Actin filaments (supported), Focal adhesion sites (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA000400 , HPA016438
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, EFO-21, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the actin filaments & focal adhesion sites.

Main location

Plasma membrane (supported), Cytosol (supported)

Additional location

Actin filaments (supported), Focal adhesion sites (supported)


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Antibody	Cell line	Location
HPA016438	A-431	Plasma membrane
HPA016438	A-431	Cytosol
HPA016438	U-2 OS	Plasma membrane
HPA016438	U-2 OS	Cytosol
HPA016438	U-251 MG	Nucleoplasm
HPA016438	U-251 MG	Cytosol
HPA000400	A-431	Plasma membrane
HPA000400	A-431	Cytosol
HPA000400	U-2 OS	Plasma membrane
		Actin filaments
		Focal adhesion sites
		Cytosol
HPA000400	U-251 MG	Plasma membrane
HPA000400	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ZNF185
Synonyms
Description	Zinc finger protein 185 (LIM domain) (HGNC Symbol)
Entrez gene summary	Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	152914442 - 152973480
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147394 (version 83.38)
Entrez gene	7739
UniProt	O15231 (UniProt - Evidence at protein level)
neXtProt	NX_O15231
Antibodypedia	ZNF185 antibodies

PROTEIN BROWSER

ZNF185-004	ZNF185-005	ZNF185-006	ZNF185-007	ZNF185-010	ZNF185-201	ZNF185-202	ZNF185-203	ZNF185-204	ZNF185-205	ZNF185-206

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF185-004 ENSP00000392984 ENST00000454925	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	327 aa 35 kDa	No	0
ZNF185-005 ENSP00000401766 ENST00000447792	H7C1R1 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		185 aa 19.1 kDa	No	0
ZNF185-006 ENSP00000409121 ENST00000426821	H0Y704 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	448 aa 47.4 kDa	No	0
ZNF185-007 ENSP00000359291 ENST00000370268	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	689 aa 73.5 kDa	No	0
ZNF185-010 ENSP00000359293 ENST00000370270	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	721 aa 76.9 kDa	No	0
ZNF185-201 ENSP00000312782 ENST00000318504	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	630 aa 67.3 kDa	No	0
ZNF185-202 ENSP00000313919 ENST00000318529	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	468 aa 50 kDa	No	0
ZNF185-203 ENSP00000325307 ENST00000324823	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	452 aa 48.6 kDa	No	0
ZNF185-204 ENSP00000395228 ENST00000449285	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	690 aa 73.6 kDa	No	0
ZNF185-205 ENSP00000440847 ENST00000535861	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	721 aa 76.9 kDa	No	0
ZNF185-206 ENSP00000444367 ENST00000539731	O15231 [Direct mapping] Zinc finger protein 185 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] Show all	692 aa 73.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.