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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CETN2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CETN2

Gene description

Centrin, EF-hand protein, 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA028956
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PROGNOSTIC SUMMARY

Prognostic marker in cervical cancer (favourable) and ovarian cancer (favourable).
Cervical cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA028956

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed weak to moderate cytoplasmic staining with additional nuclear positivity in several cases. A few gliomas, testicular and endometrial cancers showed strong positivity. Lymphomas were generally negative.

GENE INFORMATION

Gene name

CETN2 (HGNC Symbol)

Synonyms

CALT, CEN2

Description

Centrin, EF-hand protein, 2 (HGNC Symbol)

Entrez gene summary

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

152826973 - 152830777

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147400 (version 83.38)

Entrez gene

1069

UniProt

P41208 (UniProt - Evidence at protein level)

neXtProt

NX_P41208

Antibodypedia

CETN2 antibodies

PROTEIN BROWSER

CETN2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CETN2-001
ENSP00000359300
ENST00000370277
P41208 [Direct mapping]
Centrin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007099 [centriole replication]
GO:0007283 [spermatogenesis]
GO:0008017 [microtubule binding]
GO:0016925 [protein sumoylation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0032391 [photoreceptor connecting cilium]
GO:0032465 [regulation of cytokinesis]
GO:0032795 [heterotrimeric G-protein binding]
GO:0036064 [ciliary basal body]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051301 [cell division]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071942 [XPC complex]
Show all
172 aa
19.7 kDa
No 0

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