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Most cancer cells displayed weak to moderate cytoplasmic staining with additional nuclear positivity in several cases. A few gliomas, testicular and endometrial cancers showed strong positivity. Lymphomas were generally negative.
GENE INFORMATION
Gene name
CETN2 (HGNC Symbol)
Synonyms
CALT, CEN2
Description
Centrin, EF-hand protein, 2 (HGNC Symbol)
Entrez gene summary
Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]