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ATP6V1B2

GENERAL INFORMATION

Gene name

 ATP6V1B2

Gene description

 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2

Protein class

 Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA008147
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008147

GENE INFORMATION

Gene name

 ATP6V1B2 (HGNC Symbol)

Synonyms

 ATP6B2, HO57, VATB, Vma2, VPP3

Description

 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 20197367 - 20226819

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147416 (version 83.38)

Entrez gene

 526

UniProt

 P21281 (UniProt - Evidence at protein level)

neXtProt

 NX_P21281

Antibodypedia

 ATP6V1B2 antibodies

PROTEIN BROWSER
ATP6V1B2-001
ATP6V1B2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V1B2-001
ENSP00000276390
ENST00000276390
P21281 [Direct mapping]
V-type proton ATPase subunit B, brain isoform
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006879 [cellular iron ion homeostasis]
GO:0008286 [insulin receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0033180 [proton-transporting V-type ATPase, V1 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0042470 [melanosome]
GO:0043209 [myelin sheath]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046034 [ATP metabolic process]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
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 511 aa
56.5 kDa 		No 0
ATP6V1B2-005
ENSP00000430682
ENST00000519667
H0YC04 [Direct mapping]
V-type proton ATPase subunit B, brain isoform
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0015992 [proton transport]
GO:0046034 [ATP metabolic process]
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 199 aa
21 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.