Expression of CCDC25 in cancer - Summary - The Human Protein Atlas

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CCDC25

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC25
Gene description	Coiled-coil domain containing 25
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA023256
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023256

GENE INFORMATION
Gene name	CCDC25 (HGNC Symbol)
Synonyms	FLJ10853
Description	Coiled-coil domain containing 25 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p21.1
Chromosome location (bp)	27733311 - 27772653
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147419 (version 83.38)
Entrez gene	55246
UniProt	Q86WR0 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WR0
Antibodypedia	CCDC25 antibodies

PROTEIN BROWSER

CCDC25-001	CCDC25-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC25-001 ENSP00000348933 ENST00000356537	Q86WR0 [Direct mapping] Coiled-coil domain-containing protein 25 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	208 aa 24.5 kDa	No	0
CCDC25-009 ENSP00000428000 ENST00000522915	Q86WR0 [Direct mapping] Coiled-coil domain-containing protein 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	140 aa 16.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.