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CHRNA6

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GENERAL INFORMATION

Gene name

 CHRNA6

Gene description

 Cholinergic receptor, nicotinic, alpha 6 (neuronal)

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (Daudi, U-698, HDLM-2)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Daudi, U-698, HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CHRNA6

Synonyms

Description

 Cholinergic receptor, nicotinic, alpha 6 (neuronal) (HGNC Symbol)

Entrez gene summary

 This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 42752620 - 42796392

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000147434 (version 83.38)

Entrez gene

 8973

UniProt

 Q15825 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q15825

Antibodypedia

 CHRNA6 antibodies

PROTEIN BROWSER
CHRNA6-001
CHRNA6-004
CHRNA6-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNA6-001
ENSP00000276410
ENST00000276410
Q15825 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0014059 [regulation of dopamine secretion]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0035094 [response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0051899 [membrane depolarization]
GO:0098655 [cation transmembrane transport]
Show all
 494 aa
56.9 kDa 		Yes 4
CHRNA6-004
ENSP00000433871
ENST00000534622
Q15825 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0035094 [response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0098655 [cation transmembrane transport]
Show all
 479 aa
55 kDa 		Yes 4
CHRNA6-005
ENSP00000434659
ENST00000533810
E9PP97 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-6
Show all
Predicted intracellular proteins
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 111 aa
13.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.