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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

STAR

Gene description

Steroidogenic acute regulatory protein

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Group enriched (HEL, K-562)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in adrenal gland and Leydig cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA023644 , HPA027318 , CAB032598
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA023644
HPA027318
CAB032598

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of pancreatic, liver, ovarian and gastric cancers displayed moderate membranous and cytoplasmic immunoreactivity. Remaining malignant cells were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant melanomas showed weak to moderate cytoplasmic immunoreactivity. Remaining malignant cells were in general negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells were negative although a few cases displayed weak cytoplasmic staining.

GENE INFORMATION

Gene name

STAR (HGNC Symbol)

Synonyms

StAR, STARD1

Description

Steroidogenic acute regulatory protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p11.23

Chromosome location (bp)

38143649 - 38151265

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147465 (version 83.38)

Entrez gene

6770

UniProt

P49675 (UniProt - Evidence at protein level)

neXtProt

NX_P49675

Antibodypedia

STAR antibodies

PROTEIN BROWSER

STAR-001
STAR-005
STAR-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAR-001
ENSP00000276449
ENST00000276449
P49675 [Direct mapping]
Steroidogenic acute regulatory protein, mitochondrial
Q6IBK0 [Target identity:100%; Query identity:100%]
STAR protein; Steroidogenic acute regulator, isoform CRA_a; cDNA, FLJ96085, highly similar to Homo sapiens steroidogenic acute regulator (STAR), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0006082 [organic acid metabolic process]
GO:0006694 [steroid biosynthetic process]
GO:0006699 [bile acid biosynthetic process]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006701 [progesterone biosynthetic process]
GO:0006703 [estrogen biosynthetic process]
GO:0007420 [brain development]
GO:0007584 [response to nutrient]
GO:0007623 [circadian rhythm]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008211 [glucocorticoid metabolic process]
GO:0008289 [lipid binding]
GO:0008584 [male gonad development]
GO:0009635 [response to herbicide]
GO:0009636 [response to toxic substance]
GO:0010033 [response to organic substance]
GO:0010212 [response to ionizing radiation]
GO:0010288 [response to lead ion]
GO:0010628 [positive regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0015485 [cholesterol binding]
GO:0016101 [diterpenoid metabolic process]
GO:0017085 [response to insecticide]
GO:0017127 [cholesterol transporter activity]
GO:0017143 [insecticide metabolic process]
GO:0018879 [biphenyl metabolic process]
GO:0018894 [dibenzo-p-dioxin metabolic process]
GO:0018958 [phenol-containing compound metabolic process]
GO:0018963 [phthalate metabolic process]
GO:0030061 [mitochondrial crista]
GO:0031667 [response to nutrient levels]
GO:0032367 [intracellular cholesterol transport]
GO:0032869 [cellular response to insulin stimulus]
GO:0034698 [response to gonadotropin]
GO:0035094 [response to nicotine]
GO:0035457 [cellular response to interferon-alpha]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042747 [circadian sleep/wake cycle, REM sleep]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043434 [response to peptide hormone]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044321 [response to leptin]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045471 [response to ethanol]
GO:0046677 [response to antibiotic]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048545 [response to steroid hormone]
GO:0050769 [positive regulation of neurogenesis]
GO:0050810 [regulation of steroid biosynthetic process]
GO:0051412 [response to corticosterone]
GO:0060992 [response to fungicide]
GO:0061370 [testosterone biosynthetic process]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071236 [cellular response to antibiotic]
GO:0071248 [cellular response to metal ion]
GO:0071276 [cellular response to cadmium ion]
GO:0071312 [cellular response to alkaloid]
GO:0071320 [cellular response to cAMP]
GO:0071333 [cellular response to glucose stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0071371 [cellular response to gonadotropin stimulus]
GO:0071372 [cellular response to follicle-stimulating hormone stimulus]
GO:0071373 [cellular response to luteinizing hormone stimulus]
GO:0071378 [cellular response to growth hormone stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071872 [cellular response to epinephrine stimulus]
Show all
285 aa
31.9 kDa
No 0
STAR-005
ENSP00000430030
ENST00000521236
E5RH12 [Direct mapping]
Steroidogenic acute regulatory protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0006694 [steroid biosynthetic process]
GO:0008289 [lipid binding]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
Show all
48 aa
5.4 kDa
No 0
STAR-006
ENSP00000429009
ENST00000522050
H0YB94 [Direct mapping]
Steroidogenic acute regulatory protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0006694 [steroid biosynthetic process]
GO:0008289 [lipid binding]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0030301 [cholesterol transport]
Show all
250 aa
27.8 kDa
No 0

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