Expression of PXDNL in cancer - Summary - The Human Protein Atlas

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PXDNL

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	PXDNL
Gene description	Peroxidasin-like
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (AF22, Daudi, SH-SY5Y)
HPA (normal tissue):	Group enriched (epididymis, heart muscle, testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	PXDNL (HGNC Symbol)
Synonyms	FLJ25471, PMR1
Description	Peroxidasin-like (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband
Chromosome location (bp)	51319578 - 51809445
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147485 (version 83.38)
Entrez gene	137902
UniProt	A1KZ92 (UniProt - Evidence at protein level)
neXtProt	NX_A1KZ92
Antibodypedia	PXDNL antibodies

PROTEIN BROWSER

PXDNL-002	PXDNL-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PXDNL-002 ENSP00000348645 ENST00000356297	A1KZ92 [Direct mapping] Peroxidasin-like protein Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0004519 [endonuclease activity] GO:0004601 [peroxidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006979 [response to oxidative stress] GO:0020037 [heme binding] GO:0042744 [hydrogen peroxide catabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	1463 aa 163.7 kDa	Yes	0
PXDNL-003 ENSP00000428114 ENST00000522933	H0YAV0 [Direct mapping] Peroxidasin-like protein Show all	Predicted intracellular proteins Show all	GO:0004601 [peroxidase activity] GO:0005515 [protein binding] GO:0006979 [response to oxidative stress] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	537 aa 60.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.