Expression of MRPS28 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MRPS28

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPS28
Gene description	Mitochondrial ribosomal protein S28
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA027202
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027202

GENE INFORMATION
Gene name	MRPS28 (HGNC Symbol)
Synonyms	HSPC007, MRP-S28, MRPS35
Description	Mitochondrial ribosomal protein S28 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q21.13
Chromosome location (bp)	79918717 - 80030289
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147586 (version 83.38)
Entrez gene	28957
UniProt	Q9Y2Q9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2Q9
Antibodypedia	MRPS28 antibodies

PROTEIN BROWSER

MRPS28-001	MRPS28-002	MRPS28-007	MRPS28-008	MRPS28-009	MRPS28-010	MRPS28-011	MRPS28-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS28-001 ENSP00000276585 ENST00000276585	Q9Y2Q9 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005763 [mitochondrial small ribosomal subunit] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	187 aa 20.8 kDa	No	0
MRPS28-002 ENSP00000476135 ENST00000518371	U3KQQ8 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		83 aa 9.6 kDa	No	0
MRPS28-007 ENSP00000427965 ENST00000521605	E5RFT8 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.4 kDa	No	0
MRPS28-008 ENSP00000428744 ENST00000519120	E5RGC7 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.7 kDa	No	0
MRPS28-009 ENSP00000430401 ENST00000520946	E5RK86 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.4 kDa	Yes	0
MRPS28-010 ENSP00000428880 ENST00000521434	E5RFH3 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.3 kDa	Yes	0
MRPS28-011 ENSP00000428050 ENST00000519386	H0YAT2 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 15.8 kDa	No	0
MRPS28-012 ENSP00000427846 ENST00000518271	H7C5V3 [Direct mapping] 28S ribosomal protein S28, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.