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EIF3H

GENERAL INFORMATION

Gene name

 EIF3H

Gene description

 Eukaryotic translation initiation factor 3, subunit H

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA023117 , HPA023553
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable), cervical cancer (unfavourable) and liver cancer (unfavourable).
Breast cancer p<0.001
Cervical cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023117
HPA023553

GENE INFORMATION

Gene name

 EIF3H (HGNC Symbol)

Synonyms

 eIF3-gamma, eIF3-p40, eIF3h, EIF3S3

Description

 Eukaryotic translation initiation factor 3, subunit H (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

Chromosome location (bp)

 116642130 - 116766925

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147677 (version 83.38)

Entrez gene

 8667

UniProt

 O15372 (UniProt - Evidence at protein level)

neXtProt

 NX_O15372

Antibodypedia

 EIF3H antibodies

PROTEIN BROWSER
EIF3H-001
EIF3H-003
EIF3H-004
EIF3H-007
EIF3H-008
EIF3H-009
EIF3H-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF3H-001
ENSP00000429931
ENST00000521861
O15372 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit H
Q6IB98 [Target identity:100%; Query identity:100%]
Eukaryotic translation initiation factor 3 subunit H
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001731 [formation of translation preinitiation complex]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016282 [eukaryotic 43S preinitiation complex]
GO:0033290 [eukaryotic 48S preinitiation complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0071541 [eukaryotic translation initiation factor 3 complex, eIF3m]
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 352 aa
39.9 kDa 		No 0
EIF3H-003
ENSP00000276682
ENST00000276682
B3KS98 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731 [formation of translation preinitiation complex]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0016282 [eukaryotic 43S preinitiation complex]
GO:0033290 [eukaryotic 48S preinitiation complex]
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 366 aa
41.6 kDa 		No 0
EIF3H-004
ENSP00000427908
ENST00000520813
E5RFW7 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
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 97 aa
10.1 kDa 		No 0
EIF3H-007
ENSP00000428669
ENST00000518995
E5RGU4 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit H
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
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 235 aa
26.2 kDa 		No 0
EIF3H-008
ENSP00000428195
ENST00000518949
E5RJT0 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
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 244 aa
28.4 kDa 		No 0
EIF3H-009
ENSP00000428885
ENST00000522453
E5RFH0 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
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 170 aa
18.7 kDa 		No 0
EIF3H-201
ENSP00000482724
ENST00000611080
A0A087WZK9 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit H
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731 [formation of translation preinitiation complex]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0016282 [eukaryotic 43S preinitiation complex]
GO:0033290 [eukaryotic 48S preinitiation complex]
Show all
 349 aa
39.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.