Expression of SLC39A4 in cancer - Summary - The Human Protein Atlas

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SLC39A4

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SLC39A4
Gene description	Solute carrier family 39 (zinc transporter), member 4
Protein class	Disease related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (CAPAN-2, Hep G2)
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SLC39A4 (HGNC Symbol)
Synonyms	AEZ, AWMS2, ZIP4
Description	Solute carrier family 39 (zinc transporter), member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144409742 - 144416895
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147804 (version 83.38)
Entrez gene	55630
UniProt	Q6P5W5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P5W5
Antibodypedia	SLC39A4 antibodies

PROTEIN BROWSER

SLC39A4-001	SLC39A4-002	SLC39A4-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC39A4-001 ENSP00000301305 ENST00000301305	Q6P5W5 [Direct mapping] Zinc transporter ZIP4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016324 [apical plasma membrane] GO:0030001 [metal ion transport] GO:0034224 [cellular response to zinc ion starvation] GO:0046873 [metal ion transmembrane transporter activity] GO:0055038 [recycling endosome membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0071577 [zinc II ion transmembrane transport] Show all	647 aa 68.4 kDa	Yes	6
SLC39A4-002 ENSP00000276833 ENST00000276833	A6NDY5 [Direct mapping] Zinc transporter ZIP4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	622 aa 66.2 kDa	No	6
SLC39A4-010 ENSP00000434512 ENST00000526658	E9PQ16 [Direct mapping] Zinc transporter ZIP4 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 18.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.