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NAPRT

GENERAL INFORMATION

Gene name

 NAPRT

Gene description

 Nicotinate phosphoribosyltransferase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, SK-BR-3)
HPA (normal tissue):Tissue enhanced (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in selected tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA023739 , HPA024017 , CAB068206 , CAB068207
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA023739
HPA024017
CAB068206
CAB068207

GENE INFORMATION

Gene name

 NAPRT (HGNC Symbol)

Synonyms

 NAPRT1, PP3856

Description

 Nicotinate phosphoribosyltransferase (HGNC Symbol)

Entrez gene summary

 Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 143574785 - 143578649

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147813 (version 83.38)

Entrez gene

 93100

UniProt

 Q6XQN6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6XQN6

Antibodypedia

 NAPRT antibodies

PROTEIN BROWSER
NAPRT-002
NAPRT-003
NAPRT-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NAPRT-002
ENSP00000401508
ENST00000449291
Q6XQN6 [Direct mapping]
Nicotinate phosphoribosyltransferase
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004514 [nicotinate-nucleotide diphosphorylase (carboxylating) activity]
GO:0004516 [nicotinate phosphoribosyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006769 [nicotinamide metabolic process]
GO:0006979 [response to oxidative stress]
GO:0009435 [NAD biosynthetic process]
GO:0016874 [ligase activity]
GO:0019358 [nicotinate nucleotide salvage]
GO:0019674 [NAD metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 538 aa
57.6 kDa 		No 0
NAPRT-003
ENSP00000390949
ENST00000426292
Q6XQN6 [Direct mapping]
Nicotinate phosphoribosyltransferase
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004514 [nicotinate-nucleotide diphosphorylase (carboxylating) activity]
GO:0004516 [nicotinate phosphoribosyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006769 [nicotinamide metabolic process]
GO:0006979 [response to oxidative stress]
GO:0009435 [NAD biosynthetic process]
GO:0016874 [ligase activity]
GO:0019358 [nicotinate nucleotide salvage]
GO:0019674 [NAD metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 525 aa
56.1 kDa 		No 0
NAPRT-004
ENSP00000405670
ENST00000435154
C9J8U2 [Direct mapping]
Nicotinate phosphoribosyltransferase; Nicotinate phosphoribosyltransferase domain containing 1, isoform CRA_e
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004514 [nicotinate-nucleotide diphosphorylase (carboxylating) activity]
GO:0004516 [nicotinate phosphoribosyltransferase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0009435 [NAD biosynthetic process]
GO:0019358 [nicotinate nucleotide salvage]
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 490 aa
52.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.