Fields »
ABOUT
HELP
BLOG
NFIB

GENERAL INFORMATION

Gene name

 NFIB

Gene description

 Nuclear factor I/B

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AN3-CA)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA003956
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003956

GENE INFORMATION

Gene name

 NFIB (HGNC Symbol)

Synonyms

 NFI-RED, NFIB2, NFIB3

Description

 Nuclear factor I/B (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

Chromosome location (bp)

 14081843 - 14398983

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147862 (version 83.38)

Entrez gene

 4781

UniProt

 O00712 (UniProt - Evidence at protein level)

neXtProt

 NX_O00712

Antibodypedia

 NFIB antibodies

PROTEIN BROWSER
«
NFIB-001
NFIB-002
NFIB-003
NFIB-004
NFIB-005
NFIB-006
NFIB-007
NFIB-008
NFIB-009
NFIB-010
NFIB-201
NFIB-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFIB-001
ENSP00000370346
ENST00000380959
O00712 [Direct mapping]
Nuclear factor 1 B-type
Q5VW28 [Target identity:100%; Query identity:100%]
Nuclear factor 1
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010001 [glial cell differentiation]
GO:0021740 [principal sensory nucleus of trigeminal nerve development]
GO:0021960 [anterior commissure morphogenesis]
GO:0043392 [negative regulation of DNA binding]
GO:0044300 [cerebellar mossy fiber]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060486 [Clara cell differentiation]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0061141 [lung ciliated cell differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:1902894 [negative regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development]
GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]
Show all
 420 aa
47.4 kDa 		No 0
NFIB-002
ENSP00000380709
ENST00000397579
Q5VW27 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 487 aa
54.9 kDa 		No 0
NFIB-003
ENSP00000380711
ENST00000397581
Q5VW26 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 570 aa
63.4 kDa 		No 0
NFIB-004
ENSP00000380705
ENST00000397575
Q5VW30 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 561 aa
62.6 kDa 		No 0
NFIB-005
ENSP00000370340
ENST00000380953
O00712 [Direct mapping]
Nuclear factor 1 B-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008285 [negative regulation of cell proliferation]
GO:0010001 [glial cell differentiation]
GO:0021740 [principal sensory nucleus of trigeminal nerve development]
GO:0021960 [anterior commissure morphogenesis]
GO:0030324 [lung development]
GO:0030900 [forebrain development]
GO:0030902 [hindbrain development]
GO:0043392 [negative regulation of DNA binding]
GO:0044300 [cerebellar mossy fiber]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060486 [Clara cell differentiation]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0060662 [salivary gland cavitation]
GO:0060689 [cell differentiation involved in salivary gland development]
GO:0061141 [lung ciliated cell differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:1902894 [negative regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development]
GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]
Show all
 494 aa
55.2 kDa 		No 0
NFIB-006
ENSP00000370308
ENST00000380921
Q5W0Y9 [Direct mapping]
Nuclear factor 1 B-type
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 200 aa
23.6 kDa 		No 0
NFIB-007
ENSP00000475362
ENST00000493697
U3KPY9 [Direct mapping]
Nuclear factor 1 B-type
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 167 aa
19.7 kDa 		No 0
NFIB-008
ENSP00000370311
ENST00000380924
Q5VW31 [Direct mapping]
Nuclear factor 1 B-type
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 168 aa
18.4 kDa 		No 0
NFIB-009
ENSP00000475813
ENST00000606230
U3KQE8 [Direct mapping]
Nuclear factor 1 B-type
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 59 aa
7.2 kDa 		No 0
NFIB-010
ENSP00000370321
ENST00000380934
A0A0A0MRX8 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 446 aa
50.3 kDa 		No 0
NFIB-201
ENSP00000442888
ENST00000543693
O00712 [Direct mapping]
Nuclear factor 1 B-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010001 [glial cell differentiation]
GO:0021740 [principal sensory nucleus of trigeminal nerve development]
GO:0021960 [anterior commissure morphogenesis]
GO:0043392 [negative regulation of DNA binding]
GO:0044300 [cerebellar mossy fiber]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060486 [Clara cell differentiation]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0061141 [lung ciliated cell differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:1902894 [negative regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development]
GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]
Show all
 309 aa
33.5 kDa 		No 0
NFIB-202
ENSP00000481181
ENST00000622520
A0A087WXP2 [Direct mapping]
Nuclear factor 1 B-type
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 188 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.